Locate base pointers and then track the values maybe? :x just throwing out ideas.. I mean even if the information is incorrect after the read (It wont fail instantly as memory works that way) having the base pointers you can track them and see which functions are using them.. and where, then you know what type of variable it is etc.
 
Edit:
This is probably something you'll have to do since you'll probably want to hook the game up onto your own DLL so that you can add content and change logics etc.. Fix bugs.